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Article

Transcriptome-Wide Structural Equation Modeling of 13 Major Psychiatric Disorders for Cross-Disorder Risk and Drug Repurposing.

JAMA psychiatry - 1 Aug 2023

Grotzinger Andrew D, Singh Kritika, Miller-Fleming Tyne W, Lam Max, Mallard Travis T, Chen Yu, Liu Zhaowen, Ge Tian, Smoller Jordan W

Abstract excerpt

Importance: Psychiatric disorders display high levels of comorbidity and genetic overlap, necessitating multivariate approaches for parsing convergent and divergent psychiatric risk pathways. Identifying gene expression patterns underlying cross-disorder risk also stands to propel drug discovery and repurposing in the face of rising levels of polypharmacy. Objective: To identify gene expression patterns...

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Identifiers

PMID: 37314780
DOI: 10.1001/jamapsychiatry.2023.1808
PMCID: PMC10267850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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