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HepaClear, a blood-based panel combining novel methylated CpG sites and protein markers, for the detection of early-stage hepatocellular carcinoma

12 Jun 2023

Abstract excerpt

BACKGROUND: Early screening and detection of hepatocellular carcinoma (HCC) can efficiently improve patient prognosis. We aimed to identify a series of hypermethylated DNA markers and develop a blood-based HCC diagnosis panel containing DNA methylation sites and protein markers with improved sensitivity for early-stage HCC detection. RESULTS: Overall, 850K methylation arrays were performed using paired tissue DNA...

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Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Hepatocellular Carcinoma Treatment and Prognosis

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PMID: 37308980
DOI: 10.1186/s13148-023-01508-7

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