Article
Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
Cancer immunology research - 1 Sept 2023
Savage Hannah, Pareek Sumedha, Lee Jonghae, Ballarò Riccardo, Conterno Minussi Darlan, Hayek Karma, Sadullozoda Mumina, Lochmann Brooke S, McQuade Jennifer L, LaVoy Emily C, Marmonti Enrica, Patel Hetal, Wang Guangyu, Imanishi Masaki, Kotla Sivareddy, Abe Jun-Ichi, Schadler Keri
Abstract excerpt
Exercise changes the tumor microenvironment by remodeling blood vessels and increasing infiltration by cytotoxic immune cells. The mechanisms driving these changes remain unclear. Herein, we demonstrate that exercise normalizes tumor vasculature and upregulates endothelial expression of VCAM1 in YUMMER 1.7 and B16F10 murine models of melanoma but differentially regulates tumor growth, hypoxia, and the immune...
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