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Heterogeneity of CD8 T-Cell Changes in Advanced Melanomas After Initiation of Immunotherapy

3 Jul 2025

Abstract excerpt

Whole-body CD8+ T-cell PET imaging can detect spatial and temporal localization of CD8+ T cells. To obtain insight into early CD8+ T-cell response to immunotherapy in patients with melanoma, a highly immunogenic tumor, we performed serial PET imaging with the 1-armed CD8 antibody tracer 89ZED88082A. Methods: Immunotherapy-naïve adult patients with stage IV melanoma underwent PET scanning 2 d after receiving 10 mg...

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PMID: 40610232
DOI: 10.2967/jnumed.124.269313

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