Article
Interplays of mutations in waaA, cmk, and ail contribute to phage resistance in Yersinia pestis.
Frontiers in cellular and infection microbiology - 1 Jan 2023
Xiao Lisheng, Qi Zhizhen, Song Kai, Lv Ruichen, Chen Rong, Zhao Haihong, Wu Hailian, Li Cunxiang, Xin Youquan, Jin Yong, Li Xiang, Xu Xiaoqing, Tan Yafang, Du Zongmin, Cui Yujun, Zhang Xuefei, Yang Ruifu, Zhao Xilin, Song Yajun
Abstract excerpt
Plague caused by Yersinia pestis remains a public health threat worldwide. Because multidrug-resistant Y. pestis strains have been found in both humans and animals, phage therapy has attracted increasing attention as an alternative strategy against plague. However, phage resistance is a potential drawback of phage therapies, and the mechanism of phage resistance in Y. pestis is yet to be investigated. In this...
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