Article
KRAS G12C Mutant Non-Small Cell Lung Cancer Linked to Female Sex and High Risk of CNS Metastasis: Population-based Demographics and Survival Data From the National Swedish Lung Cancer Registry.
Clinical lung cancer - 1 Sept 2023
Isaksson Johan, Berglund Anders, Louie Karly, Willén Linda, Hamidian Arash, Edsjö Anders, Enlund Fredrik, Planck Maria, Vikström Anders, Johansson Mikael, Hallqvist Andreas, Wagenius Gunnar, Botling Johan
Abstract excerpt
BACKGROUND: Real-world data on demographics related to KRAS mutation subtypes are crucial as targeted drugs against the p.G12C variant have been approved. METHOD: We identified 6183 NSCLC patients with reported NGS-based KRAS status in the Swedish national lung cancer registry between 2016 and 2019. Following exclusion of other targetable drivers, three cohorts were studied: KRAS-G12C (n = 848), KRAS-other...
Topics
- Male
- Female
- Humans
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
- Sweden
- Proto-Oncogene Proteins p21(ras)
- Mutation
- Registries
- Demography