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Article

Resistance to thyroid hormone α, revelation of basic study to clinical consequences.

Journal of pediatric endocrinology & metabolism : JPEM - 1 May 2016

Tang Yaling, Yu Miao, Lian Xiaolan

Abstract excerpt

In the past 3 years, 15 patients with resistance to thyroid hormone α (RTHα), nine THRA gene mutations have been reported, reforming classification of RTH. RTHα exhibits distinguished clinical manifestations from RTHβ, including growth retardation, skeletal dysplasia, impaired neurodevelopment, cardiovascular dysfunction, constipation and specific thyroid axis type. This review focuses on possible pathogenesis by...

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Identifiers

PMID: 26812777
DOI: 10.1515/jpem-2015-0286

Genes

THRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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