Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational analysis of sodium-dependent phosphate transporter SLC20A1/PiT1 gene identifies missense variations C573F, and T58A as high-risk deleterious SNPs.

Journal of biomolecular structure & dynamics - 1 May 2024

Siva Sankari G, James Remya, Payva Febby, Sivaramakrishnan Venketesh, Vineeth Kumar T V, Kanchi Subbarao, Santhy K S

Abstract excerpt

SLC20A1/PiT1 is a sodium-dependent inorganic phosphate transporter, initially recognized as the retroviral receptor for Gibbon Ape Leukemia Virus in humans. SNPs in SLC20A1 is associated with Combined Pituitary Hormone Deficiency and Sodium Lithium Counter transport. Using in silico techniques, we have screened the nsSNPs for their deleterious effect on the structure and function of SLC20A1. Screening with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Molecular Dynamics Simulation
Share to Mutation, Missense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Protein Conformation

Share to Sodium-Phosphate Cotransporter Proteins, Type III

Source

Identifiers

PMID: 37286379
DOI: 10.1080/07391102.2023.2218939

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational analysis of sodium-dependent phosphate transporter SLC20A1/PiT1 gene identifies missense variations C573F, and T58A as high-risk deleterious SNPs.PMID 37286379Read ↗

Computational analysis of functional single nucleotide polymorphisms associated with SLC26A4 gene.Semantic proximity Read ↗

Structural fold and binding sites of the human Na⁺-phosphate cotransporter NaPi-II.Semantic proximity Read ↗

Homozygous Loss-of-Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities.Semantic proximity Read ↗

Identification of mutations that causes glucose-6-phosphate transporter defect in Tunisian patients with glycogenosis type 1bSemantic proximity Read ↗

In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene.Semantic proximity Read ↗

Prediction of the most deleterious non-synonymous SNPs in the human IL1B gene: evidence from bioinformatics analyses.Semantic proximity Read ↗

A profound computational study to prioritize the disease-causing mutations in PRPS1 gene.Semantic proximity Read ↗

Genetic Association of <i>SLC47A1</i> Gene Variant (17:19571562C >T) and Bioinformatics Analyses of MATE1 Protein in Chronic Kidney Disease Patients of Pakistani OriginSemantic proximity Read ↗

Sodium-dependent phosphate cotransporters: lessons from gene knockout and mutation studies.Semantic proximity Read ↗

A new insight into structural and functional impact of single-nucleotide polymorphisms in PTEN gene.Semantic proximity Read ↗

Investigation of deleterious effects of nsSNPs in the POT1 gene: a structural genomics‐based approach to understand the mechanism of cancer developmentSemantic proximity Read ↗

Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.