Article
Metabolic buffering restricts phenotype switching in melanoma.
The EMBO journal - 1 Aug 2026
Ramírez-Sánchez Ana, Jociles-Ortega Miguel, García-Martínez José Manuel, Torrens-Martínez Irene, Martínez-Useros Javier, Louphrasitthiphol Pakavarin, Sweeney Mollie I, Morente-Carrasco Ana, Ruiz-Reyes Sergio, Redondo-Díaz Nerea, Olmos-De Blas Teresa, Fernández-Aceñero María Jesús, Rodriguez-López José N, Soga Tomoyoshi, White Richard M, Goding Colin R, Sanchez-Del-Campo Luis, García-Jiménez Custodia, Chocarro-Calvo Ana
Abstract excerpt
The impact of the metabolic microenvironment on epigenetically plastic cancer cells underpins phenotypic heterogeneity, a major cause of metastasis and therapy resistance. Nutrient limitation is a key microenvironmental stress, and can cause cells to transition from proliferative to invasive phenotypes, however, whether cancer cells have the capacity to delay phenotype switching remains unknown. Here, using...
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