Article
Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response.
PLoS pathogens - 1 Apr 2020
de Vries Dylan H, Matzaraki Vasiliki, Bakker Olivier B, Brugge Harm, Westra Harm-Jan, Netea Mihai G, Franke Lude, Kumar Vinod, van der Wijst Monique G P
Abstract excerpt
Candida bloodstream infection, i.e. candidemia, is the most frequently encountered life-threatening fungal infection worldwide, with mortality rates up to almost 50%. In the majority of candidemia cases, Candida albicans is responsible. Worryingly, a global increase in the number of patients who are susceptible to infection (e.g. immunocompromised patients), has led to a rise in the incidence of candidemia in the...
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