Article
Visual genotyping of SNPs of drug-metabolizing enzymes by tetra-primer PCR coupled with a dry-reagent DNA biosensor.
Pharmacogenomics - 1 Mar 2009
Toubanaki Dimitra K, Christopoulos Theodore K, Ioannou Penelope C, Gravanis Achille
Abstract excerpt
BACKGROUND: SNP-typing strategies involve an exponential amplification step, an allele discrimination reaction and detection of the products. Usually, allele discrimination is performed after amplification. Tetra-primer PCR allows allele discrimination during the amplification step, thereby avoiding additional genotyping reactions. However, to date, electrophoresis is the only method used for detection of...
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