Article
Azithromycin induces read-through of the nonsense Apc allele and prevents intestinal tumorigenesis in C3B6F1 ApcMin/+ mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2023
Semba Ryoko, Morioka Takamitsu, Yanagihara Hiromi, Suzuki Kenshi, Tachibana Hirotaka, Hamoya Takahiro, Horimoto Yoshiya, Imaoka Tatsuhiko, Saito Mitsue, Kakinuma Shizuko, Arai Masami
Abstract excerpt
Therapeutic strategies that promote read-through of a mutant gene have proved effective for certain non-neoplastic diseases. However, the efficacy of this approach is unproven regarding neoplastic diseases with germline nonsense mutations, including familial adenomatous polyposis. Here we examined the cancer-preventive efficacy of the macrolide antibiotic azithromycin, with a reported read-through effect, on...
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