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Article

Resorting the function of the colorectal cancer gatekeeper adenomatous polyposis coli

8 Jul 2019

Abstract excerpt

As a large number of cancers are caused by nonsense mutations in key genes, read-through of these mutations to restore full-length protein expression is a potential therapeutic strategy. Mutations in the adenomatous polyposis coli (APC) gene initiate the majority of both sporadic and hereditary colorectal cancers (CRC) and around 30% of these mutations are nonsense mutations. Our goal was to test the feasibility...

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PMID: 31283021
DOI: 10.1002/ijc.32557

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