Article
A systems biology approach to define mechanisms, phenotypes, and drivers in PanNETs with a personalized perspective.
NPJ systems biology and applications - 3 Jun 2023
Werle Silke D, Ikonomi Nensi, Lausser Ludwig, Kestler Annika M T U, Weidner Felix M, Schwab Julian D, Maier Julia, Buchholz Malte, Gress Thomas M, Kestler Angelika M R, Kestler Hans A
Abstract excerpt
Pancreatic neuroendocrine tumors (PanNETs) are a rare tumor entity with largely unpredictable progression and increasing incidence in developed countries. Molecular pathways involved in PanNETs development are still not elucidated, and specific biomarkers are missing. Moreover, the heterogeneity of PanNETs makes their treatment challenging and most approved targeted therapeutic options for PanNETs lack objective...
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