Article
Pancreatic neuroendocrine neoplasms (pNENs): Genetic and environmental biomarkers for risk of occurrence and prognosis.
Seminars in cancer biology - 1 Jul 2025
Tacelli Matteo, Gentiluomo Manuel, Biamonte Paolo, Castano Justo P, Berković Maja Cigrovski, Cives Mauro, Kapitanović Sanja, Marinoni Ilaria, Marinovic Sonja, Nikas Ilias, Nosáková Lenka, Pedraza-Arevalo Sergio, Pellè Eleonora, Perren Aurel, Strosberg Jonathan, Campa Daniele, Capurso Gabriele
Abstract excerpt
Pancreatic neuroendocrine neoplasms (pNENs) are rare and heterogeneous tumors arising from neuroendocrine cells, representing approximately 10 % of all Gastro-Entero-Pancreatic neuroendocrine neoplasms. While most pNENs are sporadic, a subset is associated with genetic syndromes such as multiple endocrine neoplasia type 1 (MEN1) or von Hippel-Lindau disease (VHL). pNENs are further classified into functioning and...
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