Article
Convergence between germline and somatic mutations in pancreatic neuroendocrine tumors.
European journal of endocrinology - 19 May 2022
Ling Chao, Hong Xiafei, Xu Mengyue, Wang Yutong, Ma Xiaosen, Cui Yunying, Jiang Rui, Cao Dingyan, Wu Huanwen, Tong Anli, Zhao Yupei, Wu Wenming
Abstract excerpt
Objectives: The pancreatic neuroendocrine tumors (PanNETs) are a group of clinically heterogeneous neoplasms. Although previous studies illustrated the somatic mutation pattern for PanNETs, the germline mutation pattern is still unclear. Here, we comprehensively screened the underlying germline mutations in a cohort of multiple endocrine neoplasia type 1 (MEN1)-related and sporadic PanNETs to reveal the...
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