Article
Clinicopathological and molecular determinants of pancreatic neuroendocrine tumors: toward precision risk stratification.
Journal of translational medicine - 29 May 2026
Cheong Kai Xuan, Zhang Lu-Ting, Wang Ya-Zhou, Gan Wei, Liu Chen-Chen, Ying Ying, Peng Mao-Zhen, Tang Lin-Hui, Liu Liang, Wang Wen-Quan
Abstract excerpt
BACKGROUND: Pancreatic neuroendocrine tumors (PanNETs) are clinically heterogeneous, and conventional risk stratification based on tumor size, grade, and stage often fails to capture the full spectrum of biological behavior, especially among small (≤ 2 cm), non-functioning tumors where management remains controversial. MAIN BODY: Molecular profiling has revealed that the most frequently altered gene, MEN1,...
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