Article
Computational modeling and prediction of deletion mutants.
Structure (London, England : 1993) - 1 Jun 2023
Woods Hope, Schiano Dominic L, Aguirre Jonathan I, Ledwitch Kaitlyn V, McDonald Eli F, Voehler Markus, Meiler Jens, Schoeder Clara T
Abstract excerpt
In-frame deletion mutations can result in disease. The impact of these mutations on protein structure and subsequent functional changes remain understudied, partially due to the lack of comprehensive datasets including a structural readout. In addition, the recent breakthrough in structure prediction through deep learning demands an update of computational deletion mutation prediction. In this study, we deleted...
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