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Evaluation of neurotoxicity of anticancer drugs using nematode Caenorhabditis elegans as a model organism

1 Jan 2023

Abstract excerpt

It is well established that platinum-based drugs, including oxaliplatin (L-OHP) and cisplatin (CDDP), as well as microtubule inhibitors paclitaxel (PTX) and vincristine (VCR), are associated with chemotherapy-induced peripheral neuropathy (CIPN). In this study, we examined and compared the characteristics of neuropathies induced by L-OHP, CDDP, PTX, and VCR to evaluate whether Caenorhabditis elegans (C. elegans)...

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Identifiers

PMID: 37258236
DOI: 10.2131/jts.48.311

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