Article
Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas.
Journal of neurosurgery - 1 Dec 2023
Tabor Joanna K, O'Brien Joseph, Vasandani Sagar, Vetsa Shaurey, Lei Haoyi, Jalal Muhammad I, Marianayagam Neelan J, Jin Lan, Millares Chavez Miguel, Haynes Joseph, Dincer Alper, Yalcin Kanat, Aguilera Stephanie M, Omay Sacit Bulent, Mishra-Gorur Ketu, McGuone Declan, Morales-Valero Saul F, Fulbright Robert K, Gunel Murat, Erson-Omay E Zeynep, Moliterno Jennifer
Abstract excerpt
OBJECTIVE: Mutations in NF2 are the most common somatic driver mutation in sporadic meningiomas. NF2 mutant meningiomas preferentially arise along the cerebral convexities-however, they can also be found in the posterior fossa. The authors investigated whether NF2 mutant meningiomas differ in clinical and genomic features based on their location relative to the tentorium. METHODS: Clinical and whole exome...
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