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Correlations between genomic subgroup and clinical features in a cohort of more than 3000 meningiomas

2 Nov 2019

Abstract excerpt

OBJECTIVE: Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2, SMARCB1, SMARCE1, TRAF7, KLF4, POLR2A, BAP1, and members of the PI3K and Hedgehog signaling pathways. Initial associations between clinical features and genomic subgroups have been described, including location, grade, and histology. However, further...

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PMID: 31653806
DOI: 10.3171/2019.8.jns191266

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