Integrated molecular and detailed anatomical profiling identifies a prognostically adverse subtype of posterior fossa meningiomas: high-risk copy number alterations are associated with midline predilection and predict poor prognosis.

doi:10.1186/s40478-025-02083-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Integrated molecular and detailed anatomical profiling identifies a prognostically adverse subtype of posterior fossa meningiomas: high-risk copy number alterations are associated with midline predilection and predict poor prognosis.

Acta neuropathologica communications - 7 Aug 2025

Hirano Yudai, Miyawaki Satoru, Sakai Yu, Teranishi Yu, Umekawa Motoyuki, Hirata Takeru, Ogawa Shotaro, Komura Daisuke, Katoh Hiroto, Ikemura Masako, Koizumi Satoshi, Ono Hideaki, Ushiku Tetsuo, Ishikawa Shumpei, Saito Nobuhito

Abstract excerpt

Anatomical localization of meningiomas has been increasingly linked to their genetic alterations. However, studies focusing specifically on the genomic landscape and clinical implications of posterior fossa meningiomas remain limited. In this study, we investigated the genetic, anatomical, and clinical characteristics of posterior fossa meningiomas, aiming to clarify the association between genetic alterations,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Exome Sequencing

Share to Magnetic Resonance Imaging

Share to Meningioma

Share to Neurofibromin 2

Share to Prognosis

Share to Risk Assessment

Source

Open in PubMed Open full text

Identifiers

PMID: 40775657
DOI: 10.1186/s40478-025-02083-z
PMCID: PMC12329998

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated molecular and detailed anatomical profiling identifies a prognostically adverse subtype of posterior fossa meningiomas: high-risk copy number alterations are associated with midline predilection and predict poor prognosis.PMID 40775657Read ↗

Genomic Biomarkers of Meningioma: A Focused ReviewSemantic proximity Read ↗

Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic ApplicationsSemantic proximity Read ↗

The multiomic landscape of meningiomas: a review and updateSemantic proximity Read ↗

Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.Semantic proximity Read ↗

Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges.Semantic proximity Read ↗

European Association of Neuro-Oncology guideline on molecular testing of meningiomas for targeted therapy selectionSemantic proximity Read ↗

Advances in meningioma genomics, proteomics, and epigenetics: insights into biomarker identification and targeted therapiesSemantic proximity Read ↗

Clinical potential of meningioma genomic insights: a practical review for neurosurgeons.Semantic proximity Read ↗

Clinical and genomic differences in supratentorial versus infratentorial NF2 mutant meningiomas.Semantic proximity Read ↗

Distinct genomic subclasses of high-grade/progressive meningiomas: NF2-associated, NF2-exclusive, and NF2-agnosticSemantic proximity Read ↗

Molecular And Genetic Characterization Of Atypical And Anaplastic Meningioma’s Implications For Prognosis And Targeted TherapySemantic proximity Read ↗

A clinically applicable integrative molecular classification of meningiomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.