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Engineering an Optimal Y280-Lineage H9N2 Vaccine Strain by Tuning PB2 Activity

16 May 2023

Abstract excerpt

H9N2 avian influenza A viruses (AIVs) cause economic losses in the poultry industry and provide internal genomic segments for the evolution of H5N1 and H7N9 AIVs into more detrimental strains for poultry and humans. In addition to the endemic Y439/Korea-lineage H9N2 viruses, the Y280-lineage spread to Korea since 2020. Conventional recombinant H9N2 vaccine strains, which bear mammalian pathogenic internal genomes...

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PMID: 37240186
DOI: 10.3390/ijms24108840

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