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Article

Mutation-Driven S100A8 Overexpression Confers Aberrant Phenotypes in Type 1 CALR-Mutated MPN.

International journal of molecular sciences - 14 May 2023

Wang Ying-Hsuan, Chen Ying-Ju, Lai Yi-Hua, Wang Ming-Chung, Chen Yi-Yang, Wu Yu-Ying, Yang Yao-Ren, Tsou Hsing-Yi, Li Chian-Pei, Hsu Chia-Chen, Huang Cih-En, Chen Chih-Cheng

Abstract excerpt

Numerous pathogenic CALR exon 9 mutations have been identified in myeloproliferative neoplasms (MPN), with type 1 (52bp deletion; CALRDEL) and type 2 (5bp insertion; CALRINS) being the most prevalent. Despite the universal pathobiology of MPN driven by various CALR mutants, it is unclear why different CALR mutations result in diverse clinical phenotypes. Through RNA sequencing followed by validation at the...

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Identifiers

PMID: 37240094
DOI: 10.3390/ijms24108747
PMCID: PMC10217897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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