Article
HLA class II genotyping of admixed Brazilian patients with type 1 diabetes according to self-reported color/race in a nationwide study.
Scientific reports - 20 Apr 2020
Santos Deborah Conte, Porto Luís Cristóvão, Oliveira Romulo Vianna, Secco Danielle, Hanhoerderster Leonardo, Pizarro Marcela Haas, Barros Bianca S V, Mello Laura G N, Muniz Luiza Harcar, Silva Dayse A, Gomes Marília Brito
Abstract excerpt
The HLA region is responsible for almost 50% of the genetic risk of type 1 diabetes (T1D). However, haplotypes and their effects on risk or protection vary among different ethnic groups, mainly in an admixed population. We aimed to evaluate the HLA class II genetic profile of Brazilian individuals with T1D and its relationship with self-reported color/race. This was a nationwide multicenter study conducted in 10...
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