Ex vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017.

doi:10.1186/s12936-023-04588-1

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Article

Ex vivo RSA and pfkelch13 targeted-amplicon deep sequencing reveal parasites susceptibility to artemisinin in Senegal, 2017.

Malaria journal - 26 May 2023

Yade Mamadou Samb, Dièye Baba, Coppée Romain, Mbaye Aminata, Diallo Mamadou Alpha, Diongue Khadim, Bailly Justine, Mama Atikatou, Fall Awa, Thiaw Alphonse Birane, Ndiaye Ibrahima Mbaye, Ndiaye Tolla, Gaye Amy, Tine Abdoulaye, Diédhiou Younouss, Mbaye Amadou Mactar, Doderer-Lang Cécile, Garba Mamane Nassirou, Bei Amy Kristine, Ménard Didier, Ndiaye Daouda

Abstract excerpt

BACKGROUND: Malaria control is highly dependent on the effectiveness of artemisinin-based combination therapy (ACT), the current frontline malaria curative treatment. Unfortunately, the emergence and spread of parasites resistant to artemisinin (ART) derivatives in Southeast Asia and South America, and more recently in Rwanda and Uganda (East Africa), compromise their long-term use in sub-Saharan Africa, where...

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PMID: 37237307
DOI: 10.1186/s12936-023-04588-1
PMCID: PMC10223908

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