Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India.

Scientific reports - 11 May 2021

Das Sabyasachi, Kar Amrita, Manna Subhankar, Mandal Samaresh, Mandal Sayantani, Das Subhasis, Saha Bhaskar, Hati Amiya Kumar

Abstract excerpt

Artemisinin is the frontline fast-acting anti-malarial against P. falciparum. Emergence and spread of resistant parasite in eastern-India poses a threat to national malaria control programs. Therefore, the objective of our study is to evaluate the artesunate-sulfadoxine-pyrimethamine efficacy in Central India. 180 monoclonal P. falciparum-infected patients received standard ASSP therapy during August 2015-January...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Artemisinins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Malaria

Share to Malaria, Falciparum

Share to Plasmodium falciparum

Share to Pyrimethamine

Share to Sulfadoxine

Share to Tetrahydrofolate Dehydrogenase

Source

Open in PubMed Open full text

Identifiers

PMID: 33976269
DOI: 10.1038/s41598-021-89295-0
PMCID: PMC8113598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India.PMID 33976269Read ↗

Novel pfkelch13 Gene Polymorphism Associates With Artemisinin Resistance in Eastern IndiaSemantic proximity Read ↗

Clinical and molecular monitoring of Plasmodium falciparum resistance to antimalarial drug (artesunate+sulphadoxine-pyrimethamine) in two highly malarious district of Madhya Pradesh, Central India from 2012-2014.Semantic proximity Read ↗

Association of Plasmodium falciparum kelch13 R561H genotypes with delayed parasite clearance in Rwanda: an open-label, single-arm, multicentre, therapeutic efficacy study.Semantic proximity Read ↗

Artemisinin and multidrug-resistant Plasmodium falciparum - a threat for malaria control and elimination.Semantic proximity Read ↗

Profiles of Kelch mutations in Plasmodium falciparum across South Asia and their implications for tracking drug resistanceSemantic proximity Read ↗

Stable high frequencies of sulfadoxine-pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine-pyrimethamine in Ujjain, Madhya Pradesh, IndiaSemantic proximity Read ↗

Therapeutic efficacy of artemether–lumefantrine in North-Eastern states of India and prevalence of drug resistance-associated molecular markersSemantic proximity Read ↗

Stable high frequencies of sulfadoxine-pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine-pyrimethamine in Ujjain, Madhya Pradesh, India.Semantic proximity Read ↗

Surveillance of artemisinin resistance in Plasmodium falciparum in India using the kelch13 molecular marker.Semantic proximity Read ↗

Absence of Artemisinin Resistance-Associated Mutations in the Plasmodium Falciparum Kelch 13 (K13) Propeller Domain Gene Following Widespread Use of Artemisinin-Based Combination Therapy in Iran.Semantic proximity Read ↗

Polymorphisms in pfdhfr and pfdhps genes after five years of artemisinin combination therapy (ACT) implementation from urban Kolkata, India.Semantic proximity Read ↗

Updates on k13 mutant alleles for artemisinin resistance in Plasmodium falciparum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.