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Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers

13 Mar 2024

Abstract excerpt

Hantaan virus is a dangerous human pathogen whose segmented negative-stranded RNA genome is replicated and transcribed by a virally-encoded multi-functional polymerase. Here we describe the complete cryo-electron microscopy structure of Hantaan virus polymerase in several oligomeric forms. Apo polymerase protomers can adopt two drastically different conformations, which assemble into two distinct symmetric...

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PMID: 38480734
DOI: 10.1038/s41467-024-46601-4

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