Article
Trypanosoma cruzi DTU diversity, benznidazole response, and clinical manifestations of Chagas disease: a seventeen-year systematic review and meta-analysis.
Acta tropica - 1 Jun 2026
de Lima Ellen Vieira, Bertolini Vitor Klipel da Silva, Cunha Marielton Dos Passos, Miguel Danilo Ciccone, de Almeida Eros Antônio, Gadelha Fernanda Ramos
Abstract excerpt
Chagas disease (CD) typically progresses through an often-asymptomatic acute phase, followed by a chronic phase where patients may evolve to the asymptomatic, cardiac, digestive, or cardiodigestive manifestations. The first-line treatment, benznidazole (BZN), is more effective in the acute phase but often causes severe side effects. One major obstacle to treatment success is the high genetic diversity of the...
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