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Article

Proteome-wide Mendelian randomization identifies drug targets for atrial fibrillation/flutter.

BMC cardiovascular disorders - 26 Nov 2025

Jia Qi, Yang Yiyi, Chen Xiangdong, Hu Zhiqiang

Abstract excerpt

BACKGROUND: Developing effective and safe drug targets for atrial fibrillation/flutter (AF/AFL) is a critical clinical need. As the plasma proteome represents a major source of druggable targets, this study aimed to identify causal protein targets for AF/AFL and assess their potential side effects. METHODS: A two-sample Mendelian Randomization (MR) study was conducted to evaluate the causal effects of plasma...

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Share to Atrial Fibrillation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proprotein Convertase 9

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Source

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Identifiers

PMID: 41299274
DOI: 10.1186/s12872-025-05383-3
PMCID: PMC12751433

Genes

PCSK9
NFKB1
PGD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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