Article
Genome-wide association studies: utility and limitations for research in physiology.
The Journal of physiology - 1 Jul 2023
Pereira Ciochetti Nicolas, Lugli-Moraes Beatriz, Santos da Silva Bruna, Rovaris Diego Luiz
Abstract excerpt
Physiological systems are subject to interindividual variation encoded by genetics. Genome-wide association studies (GWAS) operate by surveying thousands of genetic variants from a substantial number of individuals and assessing their association to a trait of interest, be it a physiological variable, a molecular phenotype (e.g. gene expression), or even a disease or condition. Through a myriad of methods, GWAS...
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