Article
Genetic risk sum score comprised of common polygenic variation is associated with body mass index.
Human genetics - 1 Feb 2011
Peterson Roseann E, Maes Hermine H, Holmans Peter, Sanders Alan R, Levinson Douglas F, Shi Jianxin, Kendler Kenneth S, Gejman Pablo V, Webb Bradley T
Abstract excerpt
Genome-wide association studies (GWAS) of body mass index (BMI) using large samples have yielded approximately a dozen robustly associated variants and implicated additional loci. Individually these variants have small effects and in aggregate explain a small proportion of the variance. As a result, replication attempts have limited power to achieve genome-wide significance, even with several thousand subjects....
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