Ionic displacement of Ca2+ by Pb2+ in calmodulin is affected by arrhythmia-associated mutations.

Abstract excerpt

Lead is a highly toxic metal that severely perturbs physiological processes even at sub-micromolar levels, often by disrupting the Ca2+ signaling pathways. Recently, Pb2+-associated cardiac toxicity has emerged, with potential involvement of both the ubiquitous Ca2+ sensor protein calmodulin (CaM) and ryanodine receptors. In this work, we explored the hypothesis that Pb2+ contributes to the pathological phenotype...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arrhythmias, Cardiac
• Share to Calmodulin
• Share to Lead