Article
Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants.
JAMA oncology - 1 Jul 2023
Chen Xuan, Meyer Margaret A, Kemppainen Jennifer L, Horibe Masayasu, Chandra Shruti, Majumder Shounak, Petersen Gloria M, Rabe Kari G
Abstract excerpt
Importance: Increased cancer risk in first-degree relatives of probands with pancreatic ductal adenocarcinoma (PDAC probands) who carry pathogenic or likely pathogenic germline variants (PGVs) in cancer syndrome-associated genes encourages cascade genetic testing. To date, unbiased risk estimates for the development of cancers on a gene-specific basis have not been assessed. Objective: To quantify the risk of...
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