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Article

Results of a multigene panel testing approach targeting patients with suspected genetic predisposition to pancreatic ductal adenocarcinoma.

European journal of human genetics : EJHG - 1 Sept 2026

Buecher Bruno, Warcoin Mathilde, Rolland Emilie, Abdullazoda Rukhshona, Le Guillevic Aurélia, Colas Chrystelle, Golmard Lisa

Abstract excerpt

Pancreatic ductal adenocarcinoma occur in the context of a suspected or proven genetic predisposition in 5-10% of cases. While universal germline multigene panel testing is currently recommended by NCCN and ASCO, this approach was previously limited to patients with personal and/or family criteria suggestive of hereditary predisposition. We report the results of this « selective » approach applied in our...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Pancreatic Ductal
Genetic Predisposition to Disease
Female
Pancreatic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Testing

Male

Germ-Line Mutation

Middle Aged

Aged

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 41611968
DOI: 10.1038/s41431-026-02020-1
PMCID: PMC13549963

Genes

ATM
BRCA2
APC
BRCA1
CDKN2A
MLH1
MSH2
MSH6
PALB2
PMS2
RAD51C
RAD51D
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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