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Article

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.

Nature communications - 19 Feb 2021

Wu Yeda, Murray Graham K, Byrne Enda M, Sidorenko Julia, Visscher Peter M, Wray Naomi R

Abstract excerpt

Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6,...

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Identifiers

PMID: 33608531
DOI: 10.1038/s41467-021-21280-7
PMCID: PMC7895976

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