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Article

The effects of spontaneous mutation on quantitative traits. I. Variances and covariances of life history traits.

Genetics - 1 Nov 1994

Houle D, Hughes K A, Hoffmaster D K, Ihara J, Assimacopoulos S, Canada D, Charlesworth B

Abstract excerpt

We have accumulated spontaneous mutations in the absence of natural selection in Drosophila melanogaster by backcrossing 200 heterozygous replicates of a single high fitness second chromosome to a balancer stock for 44 generations. At generations 33 and 44 of accumulation, we extracted samples of chromosomes and assayed their homozygous performance for female fecundity early and late in adult life, male and...

Topics

Animals
Crosses, Genetic
Drosophila melanogaster
Female
Fertility
Genes, Lethal
Genetic Variation
Homozygote
Longevity
Male
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7851773
DOI: 10.1093/genetics/138.3.773
PMCID: PMC1206226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7851773-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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