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Aging2Cancer: an integrated resource for linking aging to tumor multi-omics data.

BMC genomics - 18 Dec 2024

Xu Dahua, Shen Yutong, Zhang Nihui, Deng Guoqing, Zheng Dehua, Li Peihu, Cai Jiale, Tian Guanghui, Wei Qingchen, Jiang Hongyan, Xu Jiankai, Wang Bo, Li Kongning

Abstract excerpt

BACKGROUND: Aging and tumorigenesis share intricate regulatory processes, that alter the genome, epigenome, transcriptome and immune landscape of tissues. Discovering the link between aging and cancer in terms of multiomics characteristics remains a challenge for biomedical researchers. METHODS: We collected high-throughput datasets for 57 human tumors and 20 normal tissues, including 23,125 samples with age...

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Aging
Databases, Genetic
DNA Copy Number Variations
DNA Methylation
Genomics

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PMID: 39695922
DOI: 10.1186/s12864-024-11150-z
PMCID: PMC11656765

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