Article
HLA antibody affinity determination: From HLA-specific monoclonal antibodies to donor HLA specific antibodies (DSA) in patient serum.
HLA - 1 Sept 2023
Hug Melanie N, Keller Sabrina, Marty Talea, Gygax Daniel, Meinel Dominik, Spies Peter, Handschin Joëlle, Kleiser Marc, Vazquez Noemi, Linnik Janina, Buchli Rico, Claas Frans, Heidt Sebastiaan, Kramer Cynthia S M, Bezstarosti Suzanne, Lee Jar-How, Schaub Stefan, Hönger Gideon
Abstract excerpt
Organs transplanted across donor-specific HLA antibodies (DSA) are associated with a variety of clinical outcomes, including a high risk of acute kidney graft rejection. Unfortunately, the currently available assays to determine DSA characteristics are insufficient to clearly discriminate between potentially harmless and harmful DSA. To further explore the hazard potential of DSA, their concentration and binding...
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