Article
A Comprehensive Evaluation of the Antibody-Verified Status of Eplets Listed in the HLA Epitope Registry.
Frontiers in immunology - 1 Jan 2021
Bezstarosti Suzanne, Bakker Kim H, Kramer Cynthia S M, de Fijter Johan W, Reinders Marlies E J, Mulder Arend, Claas Frans H J, Heidt Sebastiaan
Abstract excerpt
Matching strategies based on HLA eplets instead of HLA antigens in solid organ transplantation may not only increase the donor pool for highly sensitized patients, but also decrease the incidence of de novo donor-specific antibody formation. However, since not all eplets are equally capable of inducing an immune response, antibody verification is needed to confirm their ability to be bound by antibodies, such...
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