Article
Sensitive solid-phase detection of donor-specific antibodies as an aid highly relevant to improving allograft outcomes.
Molecular diagnosis & therapy - 1 Apr 2014
Schlaf Gerald, Pollok-Kopp Beatrix, Altermann Wolfgang W
Abstract excerpt
Transplant recipients who have had sensitizing events such as pregnancies, blood transfusions and previous transplants often develop antibodies directed against human leukocyte antigen (HLA)-molecules of the donor tissue. These pre-formed donor-specific antibodies (DSA) represent a high risk of organ failure as a consequence of antibody-mediated hyper-acute or acute allograft rejection. As a first assay to detect...
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