Sensitive solid-phase detection of donor-specific antibodies as an aid highly relevant to improving allograft outcomes.

doi:10.1007/s40291-013-0063-2

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Article

Sensitive solid-phase detection of donor-specific antibodies as an aid highly relevant to improving allograft outcomes.

Molecular diagnosis & therapy - 1 Apr 2014

Schlaf Gerald, Pollok-Kopp Beatrix, Altermann Wolfgang W

Abstract excerpt

Transplant recipients who have had sensitizing events such as pregnancies, blood transfusions and previous transplants often develop antibodies directed against human leukocyte antigen (HLA)-molecules of the donor tissue. These pre-formed donor-specific antibodies (DSA) represent a high risk of organ failure as a consequence of antibody-mediated hyper-acute or acute allograft rejection. As a first assay to detect...

Topics

Allografts
Antibody Specificity
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Graft Rejection
Graft Survival
HLA Antigens
Humans
Phenotype

Source

Open in PubMed

Identifiers

PMID: 24170304
DOI: 10.1007/s40291-013-0063-2

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