Article
Functional and phenotypic profiles of HLA-specific antibodies in relation to antibody-mediated kidney transplant rejection.
Human immunology - 1 Mar 2025
Carpenter Margaret C, Shrestha Sweta, Bharadwaj Pranay, Concetta Catalano, Sharma Shilpee, Weiner Joshua A, de Haan Noortje, Pongracz Tamas, Le Moine Alain, Holovska Vanda, Marchant Arnaud, Ackerman Margaret E
Abstract excerpt
Donor Specific Antibodies (DSAs) are associated with a higher risk of Antibody Mediated Rejection (AMR). However, not all DSAs are pathogenic, and patients that raise DSAs have a wide spectrum of outcomes ranging from the complete absence of graft injury to severe AMR. Hence, characterization of both the qualitative features and titer of DSAs has the potential to predict AMR risk and treatment outcome for...
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