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Article

Multi-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity

15 May 2023

Abstract excerpt

Abstract Background Transcriptional classification has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent discrete, mutually exclusive entities or molecular/phenotypic states with potential overlap. Therefore, we focused on the CRC Intrinsic Subtype (CRIS) classifier and evaluated whether...

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PMID: 37189167
DOI: 10.1186/s13073-023-01176-5

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