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Neuronal growth regulator 1 may modulate interleukin-6 signaling in adipocytes

28 Apr 2023

Abstract excerpt

Interleukin-6 (IL-6) is a pleiotropic cytokine that plays both anti- and pro-inflammatory roles. Due to the restricted expression of membrane IL-6 receptor (IL-6R), most pro-inflammatory functions of IL-6 are attributed to its association with soluble IL-6R (sIL-6R). Neuronal growth regulator 1 (NEGR1) is a brain-enriched membrane protein that has recently been recognized as a risk factor for many human diseases...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 37187893
DOI: 10.3389/fmolb.2023.1148521

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