Article
Brain-Restricted Inhibition of IL-6 Trans-Signaling Mildly Affects Metabolic Consequences of Maternal Obesity in Male Offspring.
Nutrients - 23 Oct 2021
Breuer Saida, Kasper Philipp, Vohlen Christina, Janoschek Ruth, Hoffmann Thorben, Appel Sarah, Müller-Limberger Elena, Mesaros Andrea, Rose-John Stefan, Garbers Christoph, Müller Stefan, Lackmann Jan-Wilm, Mahabir Esther, Dötsch Jörg, Hucklenbruch-Rother Eva, Bae-Gartz Inga
Abstract excerpt
Maternal obesity greatly affects next generations, elevating obesity risk in the offspring through perinatal programming and flawed maternal and newborn nutrition. The exact underlying mechanisms are poorly understood. Interleukin-6 (IL-6) mediates its effects through a membrane-bound receptor or by trans-signaling (tS), which can be inhibited by the soluble form of the co-receptor gp130 (sgp130). As IL-6 tS...
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