Article
NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients.
Transplantation - 1 Mar 2019
Calabrese Daniel R, Chong Tiffany, Wang Angelia, Singer Jonathan P, Gottschall Marc, Hays Steven R, Golden Jeffrey A, Kukreja Jasleen, Lanier Lewis L, Tang Qizhi, Greenland John R
Abstract excerpt
BACKGROUND: Cytomegalovirus (CMV) infection is a risk factor for chronic lung allograft dysfunction (CLAD), which limits survival in lung allograft recipients. Natural killer (NK) cells that express the NKG2C receptor mediate CMV-specific immune responses. We hypothesized that NKG2C NK cells responding to CMV in the lung allograft would reduce CMV-related inflammation and would improve CLAD-free survival....
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