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Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence

11 May 2023

Abstract excerpt

Abstract Osteoarthritis (OA) is an age-related degenerative joint disease that causes progressive cartilage loss. Chondrocyte senescence is a fundamental mechanism that contributes to the imbalance of matrix homeostasis in OA by inducing senescence-associated secretory phenotype (SASP). Although OA chondrocytes are mainly exposed to oxidative and inflammatory stresses, the role of these individual stresses in...

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PMID: 37169906
DOI: 10.1038/s41598-023-34825-1

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