Effects of Oxidative Damage and Telomerase Activity on Human Articular Cartilage Chondrocyte Senescence

Abstract excerpt

Senescence compromises the ability of chondrocytes to maintain and repair articular cartilage. We hypothesized that oxidative stress and telomere loss contribute to chondrocyte senescence. To test this hypothesis, we compared the growth of human articular cartilage chondrocytes incubated in 5% O2 and 21% O2. Cells grown in 5% O2 reached 60 population doublings (PD) before senescing, but growth in 21% O2 induced...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Diabetic Foot Ulcer Assessment and Management
• Share to Osteoarthritis Treatment and Mechanisms
• Share to Telomeres, Telomerase, and Senescence