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Senescent response in inner annulus fibrosus cells in response to TNFα, H <sub>2</sub> O <sub>2</sub> , and TNFα-induced nucleus pulposus senescent secretome

2022-12-22

Abstract excerpt

Senescence, particularly in the nucleus pulposus (NP) cells, has been implicated in the pathogenesis of disc degeneration, however, the mechanism(s) of annulus fibrosus (AF) cell senescence is still not well understood. Both TNFα and H 2 O 2 , have been implicated as contributors to the senescence pathways, and their levels are increased in degenerated discs when compared to healthy discs. Thus the objective of...

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Literature Corpus work
3bbec006-51b4-5107-b259-ad77ed8c4010
DOI
10.1101/2022.12.21.521533
Open publication

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