Article
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.
Cell metabolism - 13 Sept 2016
Altshuler-Keylin Svetlana, Shinoda Kosaku, Hasegawa Yutaka, Ikeda Kenji, Hong Haemin, Kang Qianqian, Yang Yangyu, Perera Rushika M, Debnath Jayanta, Kajimura Shingo
Abstract excerpt
Beige adipocytes gained much attention as an alternative cellular target in anti-obesity therapy. While recent studies have identified a number of regulatory circuits that promote beige adipocyte differentiation, the molecular basis of beige adipocyte maintenance remains unknown. Here, we demonstrate that beige adipocytes progressively lose their morphological and molecular characteristics after withdrawing...
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